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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TNKS
All Species:
27.27
Human Site:
T437
Identified Species:
50
UniProt:
O95271
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95271
NP_003738.2
1327
142039
T437
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Chimpanzee
Pan troglodytes
XP_001137443
1327
142033
T437
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Rhesus Macaque
Macaca mulatta
XP_001090358
1327
142132
T437
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Dog
Lupus familis
XP_849388
1327
142003
T437
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Cat
Felis silvestris
Mouse
Mus musculus
NP_780300
1320
140926
T430
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Rat
Rattus norvegicus
NP_001101077
1166
126761
N357
H
L
S
L
E
M
V
N
F
K
H
P
Q
T
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508887
1320
142724
T430
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Chicken
Gallus gallus
Q5F478
990
107379
A181
R
R
A
L
H
W
A
A
Y
M
G
H
L
E
V
Frog
Xenopus laevis
NP_001088420
1303
140252
T413
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
Zebra Danio
Brachydanio rerio
Q502K3
1071
114412
G262
A
N
E
L
V
N
R
G
A
N
V
N
Q
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651410
1181
127927
H368
Y
T
G
D
T
P
L
H
L
A
V
V
S
P
D
Honey Bee
Apis mellifera
XP_396483
1166
127309
K357
S
P
E
V
V
N
F
K
H
P
Y
T
R
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001186587
1157
126547
K348
Q
A
D
L
A
K
V
K
K
Q
L
T
A
D
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.6
98.9
N.A.
96.5
72.2
N.A.
86.8
23.2
87.1
21.8
N.A.
59.4
62.7
N.A.
63.6
Protein Similarity:
100
99.6
99.7
99.1
N.A.
97
80.3
N.A.
89.1
37.4
90.9
37.3
N.A.
71.7
72.8
N.A.
74.6
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
100
6.6
100
13.3
N.A.
0
6.6
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
13.3
100
26.6
N.A.
6.6
40
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
62
8
8
0
8
0
8
8
8
8
0
0
62
54
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
62
8
0
0
0
0
0
0
0
0
0
16
8
% D
% Glu:
0
0
16
0
8
0
0
0
0
0
0
54
0
8
0
% E
% Phe:
0
0
0
0
0
0
62
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
8
0
0
8
0
0
0
0
% G
% His:
8
0
0
0
8
0
0
8
8
0
62
8
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
0
16
8
8
0
0
0
0
0
% K
% Leu:
0
8
0
85
0
0
8
0
8
54
8
0
8
0
0
% L
% Met:
0
54
0
0
0
8
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
16
0
8
0
8
0
8
0
0
8
% N
% Pro:
0
8
0
0
0
8
0
0
54
8
0
8
0
16
0
% P
% Gln:
8
0
0
0
0
54
0
0
0
8
0
0
16
0
0
% Q
% Arg:
8
8
0
0
0
0
8
0
0
0
0
0
8
0
0
% R
% Ser:
8
0
8
0
0
0
0
0
0
0
0
0
8
0
54
% S
% Thr:
0
8
0
0
8
0
0
54
0
0
0
16
0
8
8
% T
% Val:
0
0
0
8
16
0
16
0
0
0
16
8
0
0
16
% V
% Trp:
0
0
0
0
54
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _